Branislav Borenovic, one of the opposition leaders the Bosnian Serb entity Republika Srpska in the north and east of the country, announced the planned boycott on Monday.
"As of tomorrow, Serb political representatives will no longer participate in the work of the common institutions of Bosnia and Herzegovina and will not make any decisions until this issue is resolved," Borenovic told a news conference.
Following a meeting of Bosnian Serb politicians, Borenovic announced that Serb representatives would boycott the Bosnian joint presidency, the parliament and the government — effectively blocking the central institutions that rely on the approval of representatives.
"Apart from the fact that such behavior constitutes a mockery of the rule of law, I am deeply convinced that it is also sowing the seeds for potential new conflicts. Therefore, I believe that it is now necessary to regulate this matter with legal solutions," Inzko said on Friday.
The Bosnian Serb killings that took place in Srebrenica are Europe's only acknowledged genocide since the Second World War. Bosnian Serbs and neighboring Serbia do not accept the description.
Bosnian Serbs have honored their wartime leader, Radovan Karadzic, and military commander Ratko Mladic as heroes — both convicted of genocide and sentenced to life imprisonment by a Hague-based tribunal.