Dortmund left the capital empty handed, while Bayern showed their quality against Augsburg. Werder and Hannover played out a six-goal thriller and Cologne shocked Schalke. Hamburg and Freiburg drew a blank.
Mats Hummels returned to captain Borussia Dortmund, Mitch Langerak stayed in goal and Ciro Immobile led the line for Dortmund in the capital but both sides were relatively slow to start their Saturday afternoon. Klopp's side were absorbing Hertha's attacks well enough but posed little threat of their own.
Just before the break, Hertha took the lead against the run of play. Jakub Blaszczykowski, on for the injured Henrikh Mkhitaryan, lost the ball in midfield and Hertha broke forward quickly. Former BVB striker Julian Schieber showed great skill before finishing past Langerak. The Australian goalkeeper made a brilliant save just before the break to keep the scoreline at 1-0 at half time.
By the hour mark, Hertha goalkeeper Thomas Kraft had yet to make a save. Immobile's shot finally forced the former Bayern keeper into a parry before Kraft repeated the feat to keep out Hummels' powerful header.
With time running out, Immobile forced another great save out of Kraft before the Italian striker sent a free header wide. Dortmund pushed for an equalizer but couldn't find one and fell to their ninth defeat of the league season. The winter break really can't come soon enough for Klopp's men - they haven't won an away game since August.
Bayern blow away Augsburg
With what sounded like "Land of Hope and Glory" booming out of the stadium, Markus Weinzierl's side hosted Bayern Munich, who suffered their only away defeat in 32 months against Augsburg.
As expected, the hosts made it hard for Pep Guardiola's side in the opening 20 minutes. Bayern still retained near 80 percent of possession, but Alex Manninger was in good form in the Augsburg goal, notably palming away Arjen Robben's fierce strike.
Manuel Neuer demonstrated more evidence of how he has revolutionized the goalkeeping position, touching the ball 36 times in the first half and 64 overall, even winning a sliding tackle well outside of the box against Tobias Werner.
Manninger saved a Xabi Alonso header and then a low effort from Franck Ribery as Bayern pressed to break the deadlock. The Frenchman missed a good chance but then assisted Bayern's opener. Mehdi Benatia brilliantly flicked Ribery's free kick in off the post and then less than a minute later Arjen Robben curled in a lovely second off the other post to end the contest.
Robert Lewandowski threaded the needle with a finely struck third from distance, before Robben danced into the box to make it 4-0. Augsburg have been excellent this season, but the gap between themselves and the top teams in the league, particularly Bayern, remains big.
Selke saves Werder in thrilling draw
Austrian Richard Strebinger replaced an ill Raphael Wolf in between the posts. Sadly the goalkeeper couldn't prevent Lars Stindl, playing in a more attacking role, from scoring his third goal of the season to make it 1-0. Hiroshi Kiyotake and Joselu combined nicely in the box and after Bremen failed to clear on numerous occasions, Stindl finally put the ball in at the back post.
Felix Kroos cleared a Stindl header off the line and was rewarded as Bremen soon equalized. Zlatko Junuzovic curled in a sumptuous free kick, his second in three weeks, to bring the home side level. It was all square at the break, but Fin Bartels' delicate lob had to be cleared off the line by Miiko Albornoz to keep it that way at the start of the second half.
Sadly, Hannover couldn't keep the home side at bay forever. London-born attacker Melvyn Lorenzen curled in a well-placed shot after cutting in from the left wing to restore Werder's lead. That lead didn't last long though as Hannover not only equalized, but took the lead back in a matter of minutes.
Great work by Jimmy Briand set up a move that Joselu finished off at the near post and the striker was then on hand - from what looked like an offside position - to flick on Kiyotake's free kick to make it 3-2 Hannover.
Gebre Selassie forced a good save out of Ron-Robert Zieler, but with two minutes left substitute Davie Selke poked home from close range to level the scores yet again. The result will have frustrated Werder, who remain second bottom of the table.
Since Di Matteo has taken over, Schalke have collected 15 points in the Bundesliga - the third best record in the division. Cologne are keen to change their form of four defeats in the last five, but it was all Schalke in the first half.
Midweek hero Max Meyer had a deflected effort wide but Timo Horn had to be alert right from the start. By half time though, Schalke hadn't found a way through. Cologne hadn't even found a way forward at the end of the first 45 minutes.
Right from the start of the second half, Anthony Ujah changed all that drilling in a low, first-time shot for the opener - his sixth of the season. Schalke's first-half display looked a distant thing and when Matthias Lehmann converted a penalty after a foul by Benedikt Höwedes, Roberto di Matteo's men looked destined for defeat.
Young attacker Leroy Sane came on to score his first Bundesliga goal with five minutes to go but Peter Stöger's men held on for a long-overdue victory.
Freiburg and Mainz miss the chance to win
Freiburg coach Christian Streich broke up Friday's press conference after finding the questions too negative. In the opening minute against Hamburg, Freiburg were given the chance to find a positive but Vladimir Darida's penalty was saved by Jaroslav Drobny after Ronny Marcos caught Felix Klaus in an attempted clearance.
In Streich's 100th Bundesliga game, his side couldn't recover from the early missed penalty and got to half time level without a change in the scoreline. In the second half, both sides endeavored to find the back of the net but had to be content with sharing a point.
In Saturday's late kick game, Mainz hosted bottom-of-the-table Stuttgart. Johannes Geis' first half free kick was cancelled out by substitute Filip Kostic's fluke goal as the home side paid the price for not taking their chances.