Protesters packed into central Baghdad on Friday in the largest anti-government protest since the demonstrations erupted a month ago.
Hundreds of thousands of people gathered in Tahrir Square, many waving Iraqi flags and demanding that the government resign and that parliament be dissolved.
An estimated 350 people were wounded in Friday's demonstration after security forces fired rubber bullets and gas grenades to push protesters away from bridges leading to the Green Zone, the seat of Iraq's government.
Several thousand protesters also blocked roads leading to the country's main Gulf port of Umm Qasr, preventing trucks carrying goods from entering or leaving the area. Security forces used live rounds and tear gas against the crowds overnight in an effort to clear the blockade.
US Secretary of State Mike Pompeo said that the Iraqi government should listen to the "legitimate demands" of protesters, adding that the country's official investigation into deadly violence during the first round of protests "lacked sufficient credibility."
Since the first wave of protests began in early October, at least 250 people have been killed while an estimated 10,000 people have been injured by security forces.
Ire directed at Iran
Demonstrators in Baghdad on Friday also harshly criticized Iran's involvement in Iraqi affairs, as Iraq's top cleric warned foreign actors against interfering in the protests.
In his weekly sermon, powerful Shiite cleric Ali al-Sistani said Iraq must not be dragged into the "abyss of infighting."
"No person or group, no side with a particular view, no regional or international actor may seize the will of the Iraqi people and impose its will on them," he said in an apparent reference to Iran.
Iran emerged as a major power broker in Iraq following the overthrow of Saddam Hussein in 2003. Tehran backs Iraq's current government and maintains close ties with state-backed militias.
What began as protests against corruption, lack of jobs and poor access to electricity and clean water have now grown into calls for an overhaul of Iraq's political system — which has been in place since Saddam Hussein's ouster.
Something that has made the protests unique in Iraq's history is that public anger is not only being directed at the political elite, but the religious elite as well.
"No one represents the people, not Iran, not the parties, not the clerics. We want to take back our country," Ali Ghazi, a protester in Baghdad told news agency AFP on Thursday.
rs/aw (AP, AFP, dpa)