Borussia Mönchengladbach scored 11 goals as they beat Hastedt. Elsewhere, RB Leipzig came from behind to avoid a shock at fourth tier Viktoria Cologne, while FC Cologne hit nine past BFC Dynamo in Berlin.
BSC Hastedt 1-11 Borussia Mönchengladbach
(Kücük 88' — Hazard 2' (pen), 42', 84', Plea 8', 50', 78', Raffael 15', 30', 66', Neuhaus, 39', Hofmann 56')
Borussia Mönchengladbach recorded their biggest ever win in the German Cup as they feasted on fifth-tier side BSC Hastedt.
Thorgan Hazard, Alassano Plea and Raffael each scored hat tricks as the Bundesliga side showed no mercy against their Bremen Liga opponents.
Two goals to the good inside eight minutes, Gladbach kept their foot on the gas as they went in 6-0 up at halftime. They added another five after the break, but Diyar Kücük gave the home fans reason to cheer two minutes from time when he notched up a consolation for the Bremen-based side.
Viktoria Cologne 1-3 RB Leipzig
(Golley 39' — Poulsen 60', Forsberg 69', Augustin 90+3')
Emil Forsberg scored a fine second half winner as RB Leipzig recovered from being a goal down to see off Viktoria Cologne in the German Cup.
The hosts took the lead shortly before half time with a superb goal by Timm Golley, who finished off a blistering Viktoria counterattack to leave Ralf Rangnick's trailing at the break.
But Leipzig steadied the ship after the restart and got back on level terms on the hour courtesy of Yussuf Poulsen.
Forsberg then put Leipzig ahead with a rifled shot after Viktoria failed to clear, and despite Leipzig going down to 10 men when Marcelo Saracchi was red-carded, Jean-Kevin Augustin put the icing on the cake with a third in injury time.
BFC Dynamo 1-9 Cologne
Weiche Flensburg 1-0 Bochum
Karlsruher 0-6 Hannover
Jeddeloh 2-5 Heidenheim
TSV Steinbach 1-2 Augsburg
Koblenz 0-5 Fortuna Düsseldorf
Chemie Leipzig 2-1 Regensburg
Lok Stendal 0-5 Arminia Bielefeld
1860 Munich 1-3 Holstein Kiel
Jena 2-4 Union Berlin