"This war is also a war against culture, against the culture of democracy," the Green politician said during a visit to the port city of Odesa on the Black Sea.
After more than three months of conflict, she said that 375 cultural institutions had been destroyed or damaged, and 137 churches were also affected. "It becomes clear: it is about attacking the cultural identity of Ukraine," she said.
"We are now trying to send an international signal by supporting the nomination of Odesa's old town as a World Heritage City," Roth told German public broadcaster ZDF.
Roth's visit comes after an invitation from her Ukrainian counterpart, Oleksandr Tkachenko. She is the first German government official to visit the city.
Ukrainian President Volodymyr Zelenskyy also sought to highlight attacks on cultural centers in the city over the weekend, saying that artillery fire destroyed a monastery in the city.
He called the strike "proof" that Russia had no place within UNESCO, the UN's cultural agency.
Roth was scheduled to meet Odesa regional governor Maksym Marchenko and mayor Hennadiy Trukhanov. She was also set to visit some of the city's cultural institutions, such as the Odesa Film Studio and the Philharmonic Theater.
Which other German officials have visited Ukraine?