The US Food and Drug Administration (FDA) on Monday revoked its emergency authorization for two malaria drugs as potential COVID-19 treatments.
The drugs hydroxychloroquine and chloroquine — touted by President Donald Trump as a treatment for the coronavirus — are unlikely to be effective, the FDA said amid growing evidence they don't work and could cause deadly side effects.
The regulator said the drugs pose a greater risk to patients than any potential benefits.
Citing reports of heart complications, the FDA said the decades-old drugs' unproven benefits "do not outweigh the known and potential risks.''
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Researchers and their self-experiments
An oral vaccination against coronavirus
Courage, curiosity or complete hubris? It's probably a mixture of all these things that causes many scientists to test their own inventions on themselves first. According to the Global Times, a Chinese doctor not only developed an oral vaccine against the SARS-CoV-2 but also tried it out himself. So far, he hasn't seen any side effects.
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Researchers and their self-experiments
Laughing-gas party with Humphry
Scientific knowledge and private pleasure can go hand in hand. The British chemist Sir Humphry Davy experimented with nitrous oxide between 1795 and 1798. With the help of his self-experiments, he discovered not only the pain-relieving effect of the gas but also its intoxicating qualities.
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Researchers and their self-experiments
Discoverer of UV radiation
The German physicist Johann Wilhelm Ritter not only discovered ultraviolet radiation in 1801, but also invented the first battery the following year. Ritter was also interested in galvanism — a term applied to muscle contractions caused by electric shocks. The fact that he died at the age of 33 is said to have been due in part to the galvanic self-experiments with which he maltreated his body.
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Researchers and their self-experiments
Freud on cocaine
The Austrian psychologist and doctor Sigmund Freud is known as the founder of psychoanalysis. His methods are still used, discussed and criticized today. Less well known is that Freud researched the effects of cocaine during his time as a doctor at the Vienna General Hospital. Published letters show that Freud himself consumed coke for a long time and in large quantities.
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Researchers and their self-experiments
Death from yellow fever
"I believe that I am on the trail of the true pathogen," wrote the American physician Jesse Lazear on September 8, 1900, in a letter to his wife. Lazear researched malaria and yellow fever. He confirmed that the latter is transmitted by mosquitoes. To study the disease, he intentionally allowed himself to be stung, fell ill and died 17 days after writing the letter. Lazear was only 34 years old.
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Researchers and their self-experiments
The fastest man on earth
John Paul Stapp became known as the "fastest man on earth" because of his research on the effects of acceleration forces on the human body — including his own: He had himself accelerated on a so-called rocket sled up to more than 1,000 kph (621 mph) and decelerated completely in 1.4 seconds. It is the highest acceleration that a human being has ever voluntarily withstood.
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Researchers and their self-experiments
Secret heart catheter
Werner Forssmann was already considered a troublemaker during his medical training. The German surgeon was determined to prove that a long, flexible catheter could be inserted safely from the crook of the arm to the heart. Although his superiors had expressly forbidden him to carry out the experiment, in 1929 Forssmann was the first person to try it out — on himself. Secretly, of course.
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Researchers and their self-experiments
Nobel Prize winner — posthumously
The Canadian physician Ralph Steinman fell ill with pancreatic cancer and underwent an immunotherapy he developed himself. According to his physician, this therapy was unable to prevent Steinman's death, but — contrary to the prognosis — could possibly have prolonged his life by over four years. Steinman died in 2011, a few days before the Nobel Prize was awarded, which he received posthumously.
Author: Julia Vergin (fs)
Read more: Hydroxychloroquine: Using anti-malaria drug is a risky business
Off-label
Monday's revocation means that shipments of the drugs obtained by the federal government will no longer be distributed to state and local health authorities.
The drugs are still available for alternate uses, so US doctors could still prescribe them for COVID-19 in a practice known as off-label prescribing.
Trump aggressively promoted the drug during the first weeks of the outbreak and stunned medical professionals when he claimed that he was taking the drug preemptively against infection. This prompted several countries and organizations, including the WHO, to look into its possible efficacy, but most such studies have since ceased.
Read more: COVID-19 vaccine search: Germany buys stake in CureVac
kw/msh (AFP, AP, Reuters)
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Coronavirus: The consequences for tourism
Despite pandemic, skiers rush to German resorts
It's snowing in the Alps and the lower German mountain ranges. Despite all appeals, people are drawn outdoors. In many places, the perfect winter sports conditions are leading to kilometer-long traffic jams, overcrowded parking lots and full slopes, like here in Winterberg. Many municipalities can no longer control the rush and are moving to seal off their ski areas.
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Coronavirus: The consequences for tourism
Australians allowed quarentine-free travel to New Zealand again from 2021
New Zealand is setting up a "travel bubble" with neighboring Australia. After months of border closures due to the coronavirus pandemic, New Zealand will once again allow tourists from Australia to enter the country without quarantine requirements in the New Year. New Zealanders have been able to travel to Australia again since October without having to go into quarantine.
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Coronavirus: The consequences for tourism
After an eight-month break Aida Cruises launches cruise again
On Saturday (December 5) the first Aida cruise ship is scheduled to leave for a one-week trip to the Canary Islands. The ship, designed for 3300 passengers, will reportedly be 50 percent full. All passengers will need to provide a negative coronavirus test, no more than 72 hours old. On board, strict hygiene and distancing rules apply, and only guided shore excursions will be possible.
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Coronavirus: The consequences for tourism
Australian airline to introduce obligatory vaccination
Australian airline Qantas wants to introduce compulsory vaccination for intercontinental flights. "We will require international travelers to be vaccinated before we allow them on board," Qantas CEO Alan Joyce stated. The general terms and conditions would be adjusted accordingly. Whether this will also be a requirement for domestic flights has not yet been decided.
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Coronavirus: The consequences for tourism
Hong Kong and Singapore to launch 'travel bubble'
Both cities will launch a 'travel bubble' on November 22, which will allow people to move quarantine free in each direction, their governments announced on Wednesday (Nov 11), in a rare piece of good news for the pandemic-battered tourism industry. A quota of 200 residents from each city will be able to travel on one daily bubble flight to the other.
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Coronavirus: The consequences for tourism
Machu Picchu is open again
Machu Picchu, the ancient Inca city in the Peruvian Andes mountains, has reopened almost eight months after it was closed down due to the Covid-19 pandemic. Peruvian authorities organized an Inca ritual to mark the reopening. To allow for distancing, a maximum of 675 tourists per day are allowed to enter the old Inca city. That is less than a third of the normal number allowed.
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Coronavirus: The consequences for tourism
Rio cancels its famous carnival parade for the first time in a century
Rio de Janeiro's famous annual Carnival spectacle will not go ahead in February. Organizers said the spread of the coronavirus in Brazil made it impossible to safely hold parades which with some seven million people celebrating are a cultural mainstay, tourism magnet and, for many, a source of livelihood. Brazil has the second highest death rate in the world after the United States and India.
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Coronavirus: The consequences for tourism
Germany to enter a one-month lockdown
To curb the spread of the coronavirus pandemic the German government has announced though new measures to start Monday, November 2. The new restrictions effect the travel business as overnight stays in hotels for tourist purposes will be banned, entertainment facilities such as theaters and cinemas will be closed as will bars and restaurants, which will only be allowed to offer take out services.
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Coronavirus: The consequences for tourism
Nuremberg cancels Christmas market
The city announced on Monday (Oct.26) that this decision had been made in view of the rapidly increasing number of coronavirus cases. The mayor explained that it was to be assumed that in the near future the Covid-19 traffic light in Nuremberg will change to dark red. "Against this background, we think it would be the wrong signal to go ahead with the annual Christkindlesmarkt Christmas market.
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Coronavirus: The consequences for tourism
Canary Islands no longer a coronavirus risk area
The Canary Islands are no longer on the list of corona risk areas, the Robert Koch Institute announced on Thursday (Oct. 22). The abolition of the travel warning for the Canary Islands should above all please tour operators. For them, the islands off the coast of Africa with their year-round summer climate are one of the most important sources of hope for the winter season.
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Coronavirus: The consequences for tourism
Cuba re-opens to international tourism
Starting October 15, some of the Caribbean state have been reopened for international flights, with Havana a notable exception. Every visitor is tested for the coronavirus upon arrival, and a team of doctors is available in every hotel. The German vacation airline Condor plans to offer flights to Cuba's most popular tourist destination, the Varadero peninsula, starting October 31.
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Coronavirus: The consequences for tourism
Japan, South Korea among next in line for Australia travel bubble
Discussions are underway between Australia and low-risk countries across Asia and the Pacific to lift coronavirus travel restrictions, but the government has warned that travel to the US and Europe may not be an option until 2022. From Friday, Australia will open its international borders for the first time since March, allowing visitors from New Zealand to travel to the country quarantine-free.
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Coronavirus: The consequences for tourism
Global cruise ship association to require coronavirus tests for all
The cruise industry has decided to make coronavirus testing mandatory for all guests and crew members aboard cruise ships. The Cruise Lines International Association, the world’s largest such organization, announced on October 8 that passengers can only board ships by providing proof of a negative test result. All member shipping companies worldwide must now comply with this rule.
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Coronavirus: The consequences for tourism
German government declares all of Belgium and Iceland risk areas
In the wake of significant increases in coronavirus infection figures in Europe, Berlin has announced further EU countries as risk areas for travelers. In addition to Belgium and Iceland, additional areas of France and Great Britain, including all of Northern Ireland and Wales, were also classified as risk areas on September 30.
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Coronavirus: The consequences for tourism
Thailand to slowly restart tourism with flight from China
Thailand is to receive its first foreign vacationers when a flight from China arrives next week, marking the gradual restart of a vital tourism sector battered by coronavirus travel curbs, a senior official said on Tuesday. The first flight will carry some 120 tourists from Guangzhou, flying directly to the resort island of Phuket.
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Coronavirus: The consequences for tourism
Taj Mahal reopens for tourists
India's most famous building was closed for six months, but since Monday ( September 21) it can be visited again, under strict restrictions. Only 5000 online tickets will be issued per day. There are temperature checks at the entrance. Selfies are allowed, group photos are prohibited. The Taj Mahal is a UNESCO World Heritage Site and is normally visited by 8 million people every year.
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Coronavirus: The consequences for tourism
Germany extends travel warnings to include Budapest, Vienna, Amsterdam
The Foreign Ministry has reacted to higher numbers of coronavirus infections on September 16 by issuing further travel warnings, including Vienna and Budapest. The province of North Holland with Amsterdam as well as South Holland with the cities of The Hague and Rotterdam are also affected. New risk areas were also identified in the Czech Republic, Romania, Croatia, France, and Switzerland.
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Coronavirus: The consequences for tourism
Historical sales losses in global tourism
Because of the coronavirus pandemic, the tourism sector has suffered a loss of 460 billion dollars (388 billion euros) from January to June, the World Tourism Organization reported in Madrid. The loss of sales was five times higher than during the international financial and economic crisis of 2009, and the total number of tourists worldwide fell by 65 percent in the first half of the year.
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Coronavirus: The consequences for tourism
Germany issues further European travel warnings
Germany’s Foreign Office has warned against unnecessary tourism to Czech capital, Prague, and the Swiss cantons Geneva and Vaud (Vaud). This also applies to the French Mediterranean island of Corsica, the French regions Auvergne-Rhones-Alpes (around Lyon), Nouvelle-Aquitaine (around Bordeaux) and Occitania (around Toulouse) as well as more Croatian Adriatic areas, such as the city of Dubrovnik.
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Coronavirus: The consequences for tourism
Berlin to start 'differentiated system' for travel warnings
The German government has extended its travel warning for around 160 countries through September 30. The advisory applies to "third countries" — i.e. countries that are not members of the EU or associated with the Schengen area. From October 1st, a "differentiated system" will apply, in which individual travel and safety information will be given for each country.
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Coronavirus: The consequences for tourism
Australia's borders to stay shut into December
Australia has extended its travel restrictions for a further three months. The borders will remain closed for visitors from abroad until at least December 17. However, the government announced that domestic travel will soon be allowed for residents of the country. An exception will be the state of Victoria, with its metropolis Melbourne, for which a lockdown has been in place since early July.
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Coronavirus: The consequences for tourism
Germany extends global travel warning
The German government has extended the travel warning for around 160 countries outside the European Union by two weeks until September 14. A spokeswoman for the German Foreign Ministry explained the move on Wednesday (Aug 26) with rising coronavirus infection rates. "The situation will not relax sufficiently by mid-September to be able to lift the worldwide travel warning," she said.
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Coronavirus: The consequences for tourism
First Mediterranean cruise has set sail
With 2,500 instead of 6,000 passengers, the MSC Grandiosa left the port of Genoa on August 16. Stops on the seven-day voyage include Naples, Palermo and Valletta. Passengers and crew were tested for coronavirus before boarding, and body temperature is to be checked on a daily basis. Rival cruise company Costa will not be offering Mediterranean cruises again until September.
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Coronavirus: The consequences for tourism
Germany declares most of Spain high-risk area
Germany's health and interior ministries have agreed that all of Spain — apart from the Canary Islands — is now a high-risk area due to a surge in cases. Spain said it was closing night clubs across the country. Restaurants, bars and similar venues would need to close by 1 a. m. and would not be allowed to take in new guests after midnight.
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Coronavirus: The consequences for tourism
COVID-19 deals tourism in Berlin a heavy blow
In the first six months of 2020, 59% fewer tourists came to Berlin than in the previous year. The Statistics Office said on August 10 that 2.7 million guests had visited Berlin, the lowest number since 2004. The slump was even worse for foreign tourists: two thirds stayed away. Since June, the figures have been recovering and are at 30 to 40% of the previous year.
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Coronavirus: The consequences for tourism
Compulsory COVID-19 tests on entry into Germany
Anyone entering Germany from a high-risk area must take a coronavirus test from August 8, after an order by Health Minister Jens Spahn. Currently, many countries are classified as risk areas, including the United States and Brazil. In the European Union, Luxembourg, the Belgian region of Antwerp and the Spanish regions of Aragon, Catalonia and Navarre were risk areas as of early August.
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Coronavirus: The consequences for tourism
Setback for cruise holidays
Norwegian cruise operator Hurtigruten has stopped all cruises on August 3 until further notice after an outbreak of the coronavirus on one of its ships. At least 40 passengers and crew members on the Roald Amundsen tested positive for COVID-19. Meanwhile, German cruise line Aida Cruises has also postponed its planned restart due to the lack of necessary permits.
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Coronavirus: The consequences for tourism
Nepal reopens Mount Everest for climbers amid COVID-19
Despite coronavirus uncertainty, Nepal has reopened Mount Everest for the autumn trekking and climbing season. To boost the struggling tourism sector the government will permit international flights to land in the country from August 17. The Himalayan country shut its borders in March just ahead of the busy spring season when hundreds of mountaineers usually flock to the country.
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Coronavirus: The consequences for tourism
Amsterdam wants fewer weekend visitors
Concerned over a possible second wave of coronavirus, Amsterdam has requested that tourists not visit the Dutch capital on weekends. Potential day-trippers should come between Monday and Thursday, the city said on July 23. The tourist influx has swelled to such a degree that recommended social distancing of 1.5 meters between people is currently not possible in the city center.
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Coronavirus: The consequences for tourism
Crowd management in alpine idyll
In order to manage tourist throngs amid the pandemic, Bavaria's Economy Minister Hubert Aiwanger is planning a live digital guiding system for visitors. Clogged streets, wild campers and overcrowding on hiking trails in the Alps — this brings popular regions such as Lake Tegernsee (photo) to their limits. The live update system is primarily intended to redirect day-trippers to less full areas.
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Coronavirus: The consequences for tourism
Flights overshadowed by fear
Holiday flights within Europe are on the move again, with passengers sitting close together. According to an opinion poll by the International Air Transport Association (IATA), 62% of those questioned are afraid of being infected by passengers in the next seat. This was identified by IATA as the main reason for the decline in willingness to travel, which is now only 45%.
Author: Andreas Kirchhoff, Susan Bonney-Cox