Both pro and anti government forces gathered in Cairo for rallies ahead of a divisive referendum - scheduled to take place on Saturday - on a new constitution that the opposition says is too Islamist.
Egypt's president and interior minister have warned that security forces will crack down on planned anti-government demonstrations. Popular anger smolders over plans to sell disputed islands to Saudi Arabia.
The Muslim Brotherhood was at the heart of the chief prosecutor's killing in 2015, said the interior minister. The chief prosecutor was the most senior official to be killed under el-Sissi's watch.
Maurizio Massari has departed Egypt after Rome was left unsatisfied by Cairo's account of how Cambridge doctoral student Giulio Regeni was killed. Egypt has said Regeni was robbed and murdered by a violent criminal gang.
Egypt has marked the fifth anniversary of a pro-democracy uprising that toppled President Hosni Mubarak. Amid raised security, there was a ban on any demonstrations not approved by police.
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