Bayern Munich hope to end a rare three-match winless drought when they host Dutch champions PSV Eindhoven. Meanwhile, Borussia Mönchengladbach hope to register their first points of their European campaign in Glasgow.
Bayern had their winning momentum halted when Atletico Madrid handed them their first defeat of the season last time out in Europe's premier club competition. The defending Bundesliga champions are aiming to get the ball rolling again when they host PSV at the Allianz Arena on Wednesday.
Since their 1-0 defeat to Atletico, one that leaves them second in their group, Bayern also dropped points against Cologne and Frankfurt in the Bundesliga. Club chairman Karl Heinz Rummenigge was quite clear that Bayern only have themselves to blame for their dip in form.
"We have to shift up a gear very quickly, or we'll have problems in the Champions League on Wednesday," said Rummenigge ahead of their third group-stage game.
A return home will be welcome as Bayern start a pair of Champions League fixtures that could help determine the winner of their group. They have won their last 13 home games in the Champions League, and with PSV only managing one win in their 18 trips to Germany, it looks like Bayern will be happy to be home.
Nevertheless, the Dutch champions have proven hard to beat of late. Atletico needed penalties to eliminate PSV in the Round of 16 last season, and a goal at the end of the first half was the difference in their rematch in the opening game of the group stage this season. Given that Bayern have allowed three separate leads to slip away in their last two games, Carlo Ancelotti's men will have to put in a committed performance if they hope to keep pace with Atletico and win their group.
"We have to get a grip," Bayern captain Philipp Lahm said. "If you believe that less than 100 percent will do, you risk losing tackles and control."
Gladbach desperate for points in Glasgow
It was always going to be a tough task for Gladbach to reach the knockout stages with Manchester City and Barcelona in their group. They were going to have to snatch a few points from at least one of those top clubs, but after their first two matches that wasn't the case.
The best chance Gladbach now have to stay in the Champions League is prevailing twice against Celtic, the only opponent in their group that did not take part in the competition last season. But the Foals are a long way from hitting the form they had entering the group stage. They are winless in their last three games and have not scored a goal in 236 minutes.
"We know that a huge task is imminent for us. We are going to Glasgow to get points, otherwise we do not need to go in the first place," Gladbach coach Andre Schubert said ahead of the game.
Celtic Park is not an easy place to visit though. Celtic's fans helped fuel an eventful 3-3 draw against Manchester City last time out. The crowd will play a part against Gladbach too, especially since the Foals have not won away from home since August.
"We know the table, so we definitely want to take something," added Schubert.