Bayer Leverkusen have to beat European champions Barcelona to have any chance of reaching the Last 16 for the third year in a row. Luis Enrique's side, already through, will travel without three key players.
Holders Barcelona will travel to Bayer Leverkusen as group winners without the services of Dani Alves, Andres Iniesta and Gerard Pique.
Alves is carrying a suspension, while Iniesta and Pique have been left behind on 'technical grounds' according to Spanish newspaper "AS". Bayer Leverkusen need to win to qualify for the knockout stages and hope results between Roma and BATE Borisov go in their favor.
German U21 international Marc-Andre ter Stegen is the number one keeper for Champions League encounters and will continue between the sticks on Wednesday. Boss Luis Enrique will be able to call upon Lionel Messi, Luis Suarez and Neymar who have scored 40 league goals combined in 13 matches. Youngsters Sergi Roberto and Rafinha have also been left behind.
The 19 players travelling to Leverkusen are: Ter Stegen, Bravo, Masip, Rakitic, Sergio, Suárez, Messi, Neymar Jr, Mascherano, Bartra, Munir, Jordi Alba, Sandro, Adriano, Vermaelen, Samper, Gumbau, Cámara and Kaptoum.